Hydroxypropyl Cellulose: Differences Between Low and High Substitution Degrees

Low-Substituted Hydroxypropyl Cellulose(L-hPC)

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Key Specifications: Hydroxypropoxy content: 7.0%–16.0%; Degree of Substitution: 0.1–0.3; Average molecular weight: 80,000–100,000 Daltons.

Appearance: White or off-white loose powder.

Key Properties

  • Solubility: Insoluble in water, swells to form colloid upon contact with water; insoluble in ethanol and acetone.
  • Excellent compressibility: Easy to compress and form, reducing tablet capping.
  • Rapid disintegration: Great volume expansion after water absorption to accelerate tablet disintegration.
  • pH stability: Stable at pH 3–11, heat-resistant and enzyme-resistant.

Main Applications

Daily chemicals: Thickener and stabilizer for creams, shampoos and lotions

Pharmaceuticals: Disintegrant, dry binder and filler for tablets; glidant for capsules.

Food industry: Emulsifier, stabilizer, thickener and film-forming agent (used in beverages, pastries, jams).

High-Substituted Hydroxypropyl Cellulose(H-HPC)

Key Specifications: Hydroxypropoxy content: 53.4%–77.5%; Degree of Substitution: 2.2–3.5; Average molecular weight: 40,000–2,500,000 Daltons.

Appearance: White or off-white fine powder.

Key Properties

  • Solubility: Soluble in cold water and various organic solvents such as methanol, ethanol and propylene glycol; precipitates at temperatures above 40–45 ℃.
  • Thermoplasticity: Suitable for hot pressing and extrusion molding. The formed film is tough, transparent and elastic.
  • Thickening and surface activity: Its aqueous solution shows pseudoplasticity and surface activity; liquid crystal state forms at high concentrations.
  • Enzyme resistance: Good biological stability and low hygroscopicity.

Main Applications

Industry: Thickener for water-based coatings, binder for ceramic and electronic pastes, biodegradable materials, liquid crystal substrates

Pharmaceuticals: Sustained-release matrix material, film coating agent, stabilizer for suspensions, thickener for eye drops.

Food: Film-forming agent for candies and chewing gums, stabilizer for beverages, edible coating.

Daily chemicals: Thickener, emulsifier and film former for high-end cosmetics, setting agent for hair spray.

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